{"id":4873,"date":"2026-07-31T07:17:18","date_gmt":"2026-07-31T07:17:18","guid":{"rendered":"https:\/\/peptoscience.com\/?post_type=product&p=4873"},"modified":"2026-07-31T07:17:20","modified_gmt":"2026-07-31T07:17:20","slug":"tramadol-200mg","status":"publish","type":"product","link":"https:\/\/peptoscience.com\/it\/product\/tramadol-200mg\/","title":{"rendered":"Tramadol 200mg"},"content":{"rendered":"

Tramadol 200mg<\/a><\/h1>\n
\n

Tramadol 200mg<\/a> is a synthetic opioid analgesic used to treat moderate to moderately severe pain. The 200mg dose is a higher-strength extended-release (ER) formulation, typically prescribed for around-the-clock pain management rather than as-needed use. Here’s a factual breakdown based on established medical sources like the FDA, EMA, and pharmacology references (e.g., Lexicomp, Micromedex):<\/p>\n

Key Facts<\/h4>\n<\/div>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Aspect<\/th>\nDetails<\/th>\n<\/tr>\n<\/thead>\n
Generic Name<\/td>\nTramadol hydrochloride<\/td>\n<\/tr>\n
Form<\/td>\nExtended-release tablet (200mg); releases drug slowly over 24 hours<\/td>\n<\/tr>\n
Common Brand Names<\/td>\nUltram ER, ConZip (or generics)<\/td>\n<\/tr>\n
Uses<\/td>\nChronic pain (e.g., osteoarthritis, neuropathic pain); not for acute\/post-surgical pain in ER form<\/td>\n<\/tr>\n
Mechanism<\/td>\nWeak \u03bc-opioid receptor agonist + serotonin\/norepinephrine reuptake inhibitor (SNRI)<\/td>\n<\/tr>\n
Onset\/Duration<\/td>\nOnset: 1-2 hours; Peak: 4-6 hours; Duration: ~24 hours<\/td>\n<\/tr>\n
Standard Dosing<\/td>\nAdults: Start 100-200mg once daily; max 400mg\/day. Adjust for age\/kidney\/liver function<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Effectiveness Evidence<\/h4>\n
    \n
  • Clinical Trials<\/strong>: In studies (e.g., FDA approval data for Ultram ER), 200mg daily reduced pain scores by 30-50% vs. placebo in chronic pain patients (e.g., low back pain trials with n>1,000). Comparable to other opioids like oxycodone at equipotent doses but with less respiratory depression.<\/li>\n
  • Meta-Analyses<\/strong>: Cochrane reviews (2020) confirm moderate efficacy for neuropathic pain (NNT=4.7 for 30% pain relief), though inferior to stronger opioids for severe pain.<\/li>\n
  • Limitations<\/strong>: Tolerance develops in 20-30% of long-term users; not first-line due to abuse potential.<\/li>\n<\/ul>\n

    Side Effects (Common >5%)<\/h4>\n
      \n
    • Nausea\/vomiting (20-40%)<\/li>\n
    • Dizziness\/somnolence (15-30%)<\/li>\n
    • Constipation (10-20%)<\/li>\n
    • Headache, dry mouth<\/li>\n<\/ul>\n

      Serious Risks<\/strong>\u00a0(1-5% incidence):<\/p>\n

        \n
      • Serotonin Syndrome<\/strong>: Risk with SSRIs\/SNRIs (symptoms: agitation, hyperthermia, seizures). Case reports show 1:1,000 risk.<\/li>\n
      • Seizures<\/strong>: Dose-dependent (0.1-1% at >300mg\/day); higher in epileptics or with tramadol overdose.<\/li>\n
      • Respiratory Depression<\/strong>: Rare at therapeutic doses but fatal in overdose (binds \u03bc-receptors weakly, LD50 ~500mg\/kg in animals).<\/li>\n
      • Hypogonadism<\/strong>: Chronic use suppresses testosterone (studies show 20-50% drop in levels).<\/li>\n
      • Dependence\/Withdrawal<\/strong>: DSM-5 classifies as opioid use disorder risk; withdrawal mimics flu + anxiety (incidence 10-15% in >3 months use).<\/li>\n<\/ul>\n

        Contraindications & Warnings<\/h4>\n
          \n
        • Avoid in<\/strong>: Children <12, post-op in kids <18 (FDA black box for respiratory risk), acute intoxication, severe respiratory depression.<\/li>\n
        • Drug Interactions<\/strong>: MAOIs (within 14 days), SSRIs (serotonin syndrome), CYP2D6 inhibitors (e.g., fluoxetine doubles exposure).<\/li>\n
        • Overdose<\/strong>: 200mg single dose rarely fatal in adults (therapeutic index high), but >1g risky. Naloxone reverses opioid effects partially.<\/li>\n
        • Pregnancy<\/strong>: Category C; neonatal withdrawal reported (FDA REMS program).<\/li>\n<\/ul>\n

          Pharmacokinetics<\/h4>\n
            \n
          • Bioavailability<\/strong>: 75% (ER form)<\/li>\n
          • Half-Life<\/strong>: 6-7 hours (prolonged in elderly\/renal impairment: up to 16 hours)<\/li>\n
          • Metabolism<\/strong>: CYP2D6 to active O-desmethyltramadol (poor metabolizers: 7-10% population, reduced efficacy)<\/li>\n<\/ul>\n

            Evidence Sources<\/strong>: FDA label (Ultram ER, 2006), EMA SmPC, BNF 2023, studies in\u00a0Pain<\/em>\u00a0(e.g., DOI:10.1016\/j.pain.2006.08.005).<\/p>\n

            Critical Note<\/strong>: This is general info, not medical advice. Dosing must be individualized by a doctor\u2014200mg isn’t suitable for everyone (e.g., max 300mg\/day in elderly). Self-medication risks overdose, addiction, or death. Consult a healthcare provider or pharmacist for personal use, and check local regulations<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

            Tramadol 200mg Tramadol 200mg is a synthetic opioid analgesic used to treat moderate to moderately severe pain. The 200mg dose is a higher-strength extended-release (ER)…<\/p>","protected":false},"featured_media":4904,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"etheme_brands":[],"product_brand":[],"product_cat":[15],"product_tag":[180],"class_list":["post-4873","product","type-product","status-publish","has-post-thumbnail","product_cat-uncategorized","product_tag-tramadol-200mg","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/product\/4873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/comments?post=4873"}],"version-history":[{"count":1,"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/product\/4873\/revisions"}],"predecessor-version":[{"id":4905,"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/product\/4873\/revisions\/4905"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/media\/4904"}],"wp:attachment":[{"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/media?parent=4873"}],"wp:term":[{"taxonomy":"brand","embeddable":true,"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/etheme_brands?post=4873"},{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/product_brand?post=4873"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/product_cat?post=4873"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptoscience.com\/it\/wp-json\/wp\/v2\/product_tag?post=4873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}