{"id":4714,"date":"2026-07-31T07:16:56","date_gmt":"2026-07-31T07:16:56","guid":{"rendered":"https:\/\/peptoscience.com\/?post_type=product&#038;p=4714"},"modified":"2026-07-31T07:16:59","modified_gmt":"2026-07-31T07:16:59","slug":"co-codamol-15-500mg","status":"publish","type":"product","link":"https:\/\/peptoscience.com\/it\/product\/co-codamol-15-500mg\/","title":{"rendered":"Co-Codamol 15\/500mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Co-Codamol 15\/500mg<\/a><\/h1>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><strong>What it is:<\/strong><br \/>\n<a href=\"https:\/\/trusthillpharmacy.de\/\">Co-Codamol<\/a> 15\/500mg is a combination painkiller containing:<\/p>\n<ul>\n<li><strong>Codeine phosphate<\/strong>: 15 mg (an opioid analgesic that works by binding to opioid receptors in the brain to reduce pain perception).<\/li>\n<li><strong>Paracetamol (acetaminophen)<\/strong>: 500 mg (a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\">This is a lower-strength formulation (Co-Codamol 15\/500mg) compared to higher doses like 30\/500 or 8\/500. It&#8217;s available over-the-counter in some countries (e.g., UK) in limited packs, but stronger versions require a prescription.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Common Uses:<\/strong><\/p>\n<ul>\n<li>Mild to moderate pain relief (e.g., headaches, dental pain, muscle aches, period pain, post-injury soreness).<\/li>\n<li>Short-term use only (typically 3 days max for codeine-containing products to avoid dependency).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Evidence and Effectiveness:<\/strong><\/p>\n<ul>\n<li>Supported by NHS guidelines and studies in\u00a0<em>The Lancet<\/em>\u00a0(e.g., codeine-paracetamol combos provide superior analgesia to paracetamol alone for acute pain, with NNT ~4 for 50% pain relief \u2013 McQuay et al., 1990s meta-analyses).<\/li>\n<li>Co-Codamol 15\/500mg is metabolized to morphine via CYP2D6 enzyme; ~10% of people are poor metabolizers and get less benefit (FDA black box warnings on this variability).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Dosage (Adults):<\/strong><\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Age Group<\/th>\n<th>Max Daily Dose<\/th>\n<th>Notes<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Adults (16+)<\/td>\n<td>8 tablets (120 mg codeine \/ 4g paracetamol)<\/td>\n<td>1-2 tablets every 4-6 hours; do not exceed.<\/td>\n<\/tr>\n<tr>\n<td>Children (12-15)<\/td>\n<td>1 tablet every 6 hours (max 4\/day)<\/td>\n<td>Not for under 12s.<\/td>\n<\/tr>\n<tr>\n<td>Elderly\/Liver issues<\/td>\n<td>Reduce dose<\/td>\n<td>Consult doctor.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><strong>Side Effects:<\/strong><\/p>\n<ul>\n<li><strong>Common<\/strong>: Drowsiness, dizziness, constipation, nausea (codeine-related); ~20-30% incidence per clinical trials.<\/li>\n<li><strong>Serious<\/strong>: Respiratory depression (rare at low doses), addiction risk (codeine is a controlled substance), paracetamol overdose \u2192 liver failure (toxic metabolite NAPQI overwhelms glutathione stores; &gt;4g\/day risk per MHRA).<\/li>\n<li><strong>Allergic<\/strong>: Rash, swelling.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Warnings and Interactions:<\/strong><\/p>\n<ul>\n<li><strong>Do not combine with<\/strong>: Alcohol, other opioids, sedatives (increases overdose risk \u2013 see CDC opioid guidelines).<\/li>\n<li><strong>Avoid if<\/strong>: Pregnant\/breastfeeding (codeine passes into milk), asthma, liver\/kidney disease, or history of addiction.<\/li>\n<li><strong>Overdose signs<\/strong>: Vomiting, pinpoint pupils, coma \u2013 seek emergency help (naloxone for codeine; N-acetylcysteine for paracetamol).<\/li>\n<li>UK MHRA advises against codeine for children under 12 due to apnea risks (2013 ruling based on pharmacovigilance data).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Availability:<\/strong><\/p>\n<ul>\n<li>UK: OTC in pharmacies (max 16 tablets\/pack); prescription for larger amounts.<\/li>\n<li>US: Equivalent is Tylenol #2 (similar strength); codeine requires Rx.<\/li>\n<li>Always check local regulations.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\">This is general info from sources like BNF, NHS, EMA, and FDA labels \u2013\u00a0<strong>not medical advice<\/strong>. Consult a doctor or pharmacist for personal use of Co-Codamol 15\/500mg, especially if you have health conditions or take other meds. If you&#8217;re experiencing pain, describe symptoms for tailored advice.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Co-Codamol 15\/500mg What it is: Co-Codamol 15\/500mg is a combination painkiller containing: Codeine phosphate: 15 mg (an opioid analgesic that works by binding to opioid&#8230;<\/p>","protected":false},"featured_media":4729,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"etheme_brands":[],"product_brand":[],"product_cat":[62],"product_tag":[156],"class_list":["post-4714","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-co-codamol-15-500mg","first","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Co-Codamol 15\/500mg - Peptide Store<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/peptoscience.com\/it\/product\/co-codamol-15-500mg\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Co-Codamol 15\/500mg\" \/>\n<meta property=\"og:description\" content=\"Co-Codamol 15\/500mg What it is: Co-Codamol 15\/500mg is a combination painkiller containing: Codeine phosphate: 15 mg (an opioid analgesic that works by binding to opioid...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/peptoscience.com\/it\/product\/co-codamol-15-500mg\/\" \/>\n<meta property=\"og:site_name\" content=\"Peptide Store\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-31T07:16:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/photo_5096273778597104775_x.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/peptoscience.com\\\/de\\\/product\\\/co-codamol-15-500mg\\\/\",\"url\":\"https:\\\/\\\/peptoscience.com\\\/de\\\/product\\\/co-codamol-15-500mg\\\/\",\"name\":\"Co-Codamol 15\\\/500mg - 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