{"id":5183,"date":"2026-07-31T07:17:55","date_gmt":"2026-07-31T07:17:55","guid":{"rendered":"https:\/\/peptoscience.com\/?post_type=product&p=5183"},"modified":"2026-07-31T07:17:57","modified_gmt":"2026-07-31T07:17:57","slug":"promethazine-codeine-oral-solution","status":"publish","type":"product","link":"https:\/\/peptoscience.com\/es\/product\/promethazine-codeine-oral-solution\/","title":{"rendered":"Promethazine Codeine Oral Solution"},"content":{"rendered":"

Promethazine Codeine<\/a> Oral Solution<\/h1>\n

Promethazine Codeine<\/a> Oral Solution (also known as Promethazine with Codeine) is a prescription combination medication containing promethazine hydrochloride<\/strong> (an antihistamine) and codeine phosphate<\/strong> (an opioid cough suppressant). It is indicated for the temporary relief of cough and upper respiratory symptoms associated with allergies or the common cold in adults 18 years and older.<\/p>\n

Typical Composition<\/h3>\n

Each 5 mL usually contains:<\/p>\n

    \n
  • Codeine phosphate: 10 mg<\/strong><\/li>\n
  • Promethazine hydrochloride: 6.25 mg<\/strong><\/li>\n
  • Often includes 7% alcohol and a flavored syrup base<\/li>\n<\/ul>\n

    It is classified as a Schedule V controlled substance<\/strong> in the United States due to the opioid component.<\/p>\n

    Pharmacology<\/h3>\n
      \n
    • Codeine<\/strong>: Suppresses the cough reflex in the brain and provides mild pain relief and sedation.<\/li>\n
    • Promethazine<\/strong>: Blocks histamine, reduces allergy symptoms, and adds significant sedative effects.<\/li>\n<\/ul>\n

      The combination produces cough relief along with drowsiness and relaxation.<\/p>\n

      Safety Profile & Risks<\/h3>\n

      When used exactly as prescribed<\/strong> for short periods under medical supervision, it can be effective. However, it carries serious safety concerns<\/strong>:<\/p>\n

      Common Side Effects<\/strong>:<\/p>\n

        \n
      • Drowsiness and sedation<\/li>\n
      • Dizziness<\/li>\n
      • Dry mouth<\/li>\n
      • Constipation<\/li>\n
      • Nausea<\/li>\n<\/ul>\n

        Serious Risks<\/strong>:<\/p>\n

          \n
        • Respiratory depression<\/strong> (dangerously slowed breathing) \u2014 potentially life-threatening<\/li>\n
        • Addiction and physical dependence<\/strong> \u2014 Codeine is an opioid with notable abuse potential<\/li>\n
        • Overdose<\/strong>: Can cause extreme sedation, coma, respiratory failure, and death<\/li>\n
        • Increased risk in children, elderly, and people with breathing disorders<\/li>\n
        • Ultra-rapid metabolizers<\/strong> of codeine can experience dangerously high morphine levels<\/li>\n<\/ul>\n

          Major Warnings<\/h3>\n

          The FDA has issued a Black Box Warning<\/strong> for this medication due to:<\/p>\n

            \n
          • Risk of severe breathing problems in children<\/li>\n
          • Potential for life-threatening respiratory depression when combined with alcohol, benzodiazepines, other opioids, or sedatives<\/li>\n<\/ul>\n

            Abuse Potential<\/h3>\n

            This medication has a significant history of recreational misuse, often referred to as \u201clean,\u201d \u201cpurple drank,\u201d or \u201csizzurp\u201d when mixed with soda. Such use dramatically increases the risk of overdose and death.<\/p>\n

            Contraindications<\/h3>\n
              \n
            • Age under 18<\/li>\n
            • History of opioid addiction or respiratory conditions<\/li>\n
            • Pregnancy (risk of neonatal opioid withdrawal syndrome)<\/li>\n
            • Concurrent use with other CNS depressants<\/li>\n<\/ul>\n

              Important Note<\/strong>: This is a neutral, educational overview based on FDA labeling and medical sources. Promethazine Codeine Oral Solution is a controlled prescription medication<\/strong> with substantial risks of misuse, addiction, respiratory depression, and overdose. This information does not<\/strong> encourage use. Only take it exactly as prescribed by a licensed healthcare provider. Misuse can be fatal. Consult a doctor or pharmacist for any medical concerns and comply with all local laws.<\/p>","protected":false},"excerpt":{"rendered":"

              Promethazine Codeine Oral Solution Promethazine Codeine Oral Solution (also known as Promethazine with Codeine) is a prescription combination medication containing promethazine hydrochloride (an antihistamine) and…<\/p>","protected":false},"featured_media":5194,"comment_status":"open","ping_status":"closed","template":"","meta":[],"etheme_brands":[],"product_brand":[],"product_cat":[15],"product_tag":[236],"class_list":["post-5183","product","type-product","status-publish","has-post-thumbnail","product_cat-uncategorized","product_tag-promethazine-codeine-oral-solution","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"\nPromethazine Codeine Oral Solution - Peptide Store<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/peptoscience.com\/es\/product\/promethazine-codeine-oral-solution\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Promethazine Codeine Oral Solution\" \/>\n<meta property=\"og:description\" content=\"Promethazine Codeine Oral Solution Promethazine Codeine Oral Solution (also known as Promethazine with Codeine) is a prescription combination medication containing promethazine hydrochloride (an antihistamine) and...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/peptoscience.com\/es\/product\/promethazine-codeine-oral-solution\/\" \/>\n<meta property=\"og:site_name\" content=\"Peptide Store\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-31T07:17:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/photo_4945115333782080474_y.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"960\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/promethazine-codeine-oral-solution\\\/\",\"url\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/promethazine-codeine-oral-solution\\\/\",\"name\":\"Promethazine Codeine Oral Solution - 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