{"id":5183,"date":"2026-07-31T07:17:55","date_gmt":"2026-07-31T07:17:55","guid":{"rendered":"https:\/\/peptoscience.com\/?post_type=product&p=5183"},"modified":"2026-07-31T07:17:57","modified_gmt":"2026-07-31T07:17:57","slug":"promethazine-codeine-oral-solution","status":"publish","type":"product","link":"https:\/\/peptoscience.com\/es\/product\/promethazine-codeine-oral-solution\/","title":{"rendered":"Promethazine Codeine Oral Solution"},"content":{"rendered":"

Promethazine Codeine<\/a> Oral Solution<\/h1>\n

Promethazine Codeine<\/a> Oral Solution (also known as Promethazine with Codeine) is a prescription combination medication containing promethazine hydrochloride<\/strong> (an antihistamine) and codeine phosphate<\/strong> (an opioid cough suppressant). It is indicated for the temporary relief of cough and upper respiratory symptoms associated with allergies or the common cold in adults 18 years and older.<\/p>\n

Typical Composition<\/h3>\n

Each 5 mL usually contains:<\/p>\n

    \n
  • Codeine phosphate: 10 mg<\/strong><\/li>\n
  • Promethazine hydrochloride: 6.25 mg<\/strong><\/li>\n
  • Often includes 7% alcohol and a flavored syrup base<\/li>\n<\/ul>\n

    It is classified as a Schedule V controlled substance<\/strong> in the United States due to the opioid component.<\/p>\n

    Pharmacology<\/h3>\n
      \n
    • Codeine<\/strong>: Suppresses the cough reflex in the brain and provides mild pain relief and sedation.<\/li>\n
    • Promethazine<\/strong>: Blocks histamine, reduces allergy symptoms, and adds significant sedative effects.<\/li>\n<\/ul>\n

      The combination produces cough relief along with drowsiness and relaxation.<\/p>\n

      Safety Profile & Risks<\/h3>\n

      When used exactly as prescribed<\/strong> for short periods under medical supervision, it can be effective. However, it carries serious safety concerns<\/strong>:<\/p>\n

      Common Side Effects<\/strong>:<\/p>\n

        \n
      • Drowsiness and sedation<\/li>\n
      • Dizziness<\/li>\n
      • Dry mouth<\/li>\n
      • Constipation<\/li>\n
      • Nausea<\/li>\n<\/ul>\n

        Serious Risks<\/strong>:<\/p>\n

          \n
        • Respiratory depression<\/strong> (dangerously slowed breathing) \u2014 potentially life-threatening<\/li>\n
        • Addiction and physical dependence<\/strong> \u2014 Codeine is an opioid with notable abuse potential<\/li>\n
        • Overdose<\/strong>: Can cause extreme sedation, coma, respiratory failure, and death<\/li>\n
        • Increased risk in children, elderly, and people with breathing disorders<\/li>\n
        • Ultra-rapid metabolizers<\/strong> of codeine can experience dangerously high morphine levels<\/li>\n<\/ul>\n

          Major Warnings<\/h3>\n

          The FDA has issued a Black Box Warning<\/strong> for this medication due to:<\/p>\n

            \n
          • Risk of severe breathing problems in children<\/li>\n
          • Potential for life-threatening respiratory depression when combined with alcohol, benzodiazepines, other opioids, or sedatives<\/li>\n<\/ul>\n

            Abuse Potential<\/h3>\n

            This medication has a significant history of recreational misuse, often referred to as \u201clean,\u201d \u201cpurple drank,\u201d or \u201csizzurp\u201d when mixed with soda. Such use dramatically increases the risk of overdose and death.<\/p>\n

            Contraindications<\/h3>\n
              \n
            • Age under 18<\/li>\n
            • History of opioid addiction or respiratory conditions<\/li>\n
            • Pregnancy (risk of neonatal opioid withdrawal syndrome)<\/li>\n
            • Concurrent use with other CNS depressants<\/li>\n<\/ul>\n

              Important Note<\/strong>: This is a neutral, educational overview based on FDA labeling and medical sources. Promethazine Codeine Oral Solution is a controlled prescription medication<\/strong> with substantial risks of misuse, addiction, respiratory depression, and overdose. This information does not<\/strong> encourage use. Only take it exactly as prescribed by a licensed healthcare provider. Misuse can be fatal. Consult a doctor or pharmacist for any medical concerns and comply with all local laws.<\/p>","protected":false},"excerpt":{"rendered":"

              Promethazine Codeine Oral Solution Promethazine Codeine Oral Solution (also known as Promethazine with Codeine) is a prescription combination medication containing promethazine hydrochloride (an antihistamine) and…<\/p>","protected":false},"featured_media":5194,"comment_status":"open","ping_status":"closed","template":"","meta":[],"etheme_brands":[],"product_brand":[],"product_cat":[15],"product_tag":[236],"class_list":["post-5183","product","type-product","status-publish","has-post-thumbnail","product_cat-uncategorized","product_tag-promethazine-codeine-oral-solution","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product\/5183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/comments?post=5183"}],"version-history":[{"count":1,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product\/5183\/revisions"}],"predecessor-version":[{"id":5195,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product\/5183\/revisions\/5195"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/media\/5194"}],"wp:attachment":[{"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/media?parent=5183"}],"wp:term":[{"taxonomy":"brand","embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/etheme_brands?post=5183"},{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product_brand?post=5183"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product_cat?post=5183"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product_tag?post=5183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}