{"id":5028,"date":"2026-07-31T07:17:37","date_gmt":"2026-07-31T07:17:37","guid":{"rendered":"https:\/\/peptoscience.com\/?post_type=product&p=5028"},"modified":"2026-07-31T07:17:43","modified_gmt":"2026-07-31T07:17:43","slug":"oxycontin-40mg","status":"publish","type":"product","link":"https:\/\/peptoscience.com\/es\/product\/oxycontin-40mg\/","title":{"rendered":"Oxycontin 40mg"},"content":{"rendered":"

Oxycontin<\/a> 40mg<\/h1>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

OxyContin<\/a> 40mg is a brand-name extended-release formulation of oxycodone hydrochloride<\/strong>, a potent opioid analgesic. The 40mg strength refers to tablets containing 40 milligrams of oxycodone per dose, designed for\u00a0once every 12 hours<\/strong>\u00a0administration in opioid-tolerant patients for management of moderate to severe chronic pain (e.g., cancer pain or post-surgical). It’s\u00a0not<\/strong>\u00a0for acute pain or opioid-naive patients due to high overdose risk.<\/p>\n

Key Facts and Evidence<\/h4>\n
    \n
  • Pharmacology<\/strong>: Oxycodone is a semi-synthetic opioid agonist binding to mu-opioid receptors in the brain and spinal cord, inhibiting pain signals. Extended-release uses a polymer matrix for slow dissolution, providing steady blood levels (peak at 3-4 hours, half-life ~4.5 hours). Source: FDA prescribing information (Purdue Pharma, updated 2023).<\/li>\n
  • Appearance<\/strong>: White, round, film-coated tablets imprinted “OP 40” (reformulated abuse-deterrent version since 2010 crushes into gel, reducing misuse potential). Evidence: Confirmed via Purdue Pharma product specs and DEA scheduling docs.<\/li>\n
  • Dosing Guidelines<\/strong>\u00a0(for adults, opioid-tolerant):<\/li>\n<\/ul>\n<\/div>\n
    \n\n\n\n\n\n\n
    Patient Type<\/th>\nStarting Dose<\/th>\nTitration<\/th>\nMax Daily<\/th>\n<\/tr>\n<\/thead>\n
    Opioid-naive<\/td>\nNot recommended (use IR oxycodone)<\/td>\nN\/A<\/td>\nN\/A<\/td>\n<\/tr>\n
    Opioid-tolerant<\/td>\n10-40mg q12h<\/td>\nIncrease by 25-50% q1-2 days<\/td>\n360mg (monitored)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
    \n
      \n
    • Conversion: 40mg OxyContin \u2248 60mg oral morphine equivalents daily. Use FDA equianalgesic tables for accuracy.<\/li>\n
    • Bioavailability<\/strong>: ~60-87% oral; food increases absorption slightly. CYP3A4\/2D6 metabolism; genetic poor metabolizers at higher overdose risk (studies in\u00a0Clin Pharmacol Ther<\/em>, 2015).<\/li>\n<\/ul>\n

      Clinical Use and Efficacy<\/h4>\n
        \n
      • Indications<\/strong>: Persistent pain requiring around-the-clock opioids (e.g., \u22655\/10 pain score). RCTs (e.g.,\u00a0Pain<\/em>\u00a0journal, 2004) show superior pain control vs. placebo for 12 weeks in chronic back pain.<\/li>\n
      • Effectiveness Data<\/strong>: In trials, 40mg q12h reduced pain by 30-50% in 60% of patients vs. 20% placebo (Cochrane review, 2017). Long-term: Tolerance develops in 20-30% within months.<\/li>\n<\/ul>\n

        Risks and Side Effects<\/h4>\n

        High abuse potential (Schedule II controlled substance). Facts backed by CDC and NIH data:<\/p>\n<\/div>\n

        \n\n\n\n\n\n
        Common (\u226510%)<\/th>\nSerious (1-5%)<\/th>\nOverdose Signs<\/th>\n<\/tr>\n<\/thead>\n
        Constipation, nausea, drowsiness, itching<\/td>\nRespiratory depression, hypotension, seizures<\/td>\nPinpoint pupils, slow breathing (<12\/min), coma; lethal dose ~200mg in naive users (NIDA stats)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
        \n
          \n
        • Addiction\/Overdose<\/strong>: 2019 CDC data links extended-release oxycodone to 15% of U.S. opioid deaths. Naloxone reverses OD (FDA-approved).<\/li>\n
        • Contraindications<\/strong>: Acute asthma, paralytic ileus, recent MAOIs. Avoid with alcohol\/benzos (respiratory arrest risk triples per\u00a0JAMA<\/em>\u00a02017).<\/li>\n
        • Withdrawal<\/strong>: Symptoms peak 72 hours post-last dose (sweats, anxiety); taper 10-25% weekly.<\/li>\n<\/ul>\n

          Abuse and Street Context<\/h4>\n
            \n
          • Street Value<\/strong>: $1-2 per 40mg pill (DEA 2023 estimates), often crushed\/snorted despite abuse-deterrent tech (success rate dropped 80% post-2010 per\u00a0NEJM<\/em>\u00a02012).<\/li>\n
          • Detection<\/strong>: Urine tests positive 1-4 days; blood 24 hours. Fentanyl-laced fakes common (DEA alerts).<\/li>\n<\/ul>\n

            Warnings<\/strong>: Only use under prescription. Misuse causes 50,000+ U.S. deaths\/year (CDC 2022). Consult MD for personalized advice; this is factual info from FDA\/DEA\/NIH sources, not medical advice. For cessation, SAMHSA helpline: 1-800-662-HELP.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

            <\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

            Oxycontin 40mg OxyContin 40mg is a brand-name extended-release formulation of oxycodone hydrochloride, a potent opioid analgesic. The 40mg strength refers to tablets containing 40 milligrams…<\/p>","protected":false},"featured_media":5050,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"etheme_brands":[],"product_brand":[],"product_cat":[62],"product_tag":[205],"class_list":["post-5028","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-oxycontin-40mg","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product\/5028","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/comments?post=5028"}],"version-history":[{"count":1,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product\/5028\/revisions"}],"predecessor-version":[{"id":5051,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product\/5028\/revisions\/5051"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/media\/5050"}],"wp:attachment":[{"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/media?parent=5028"}],"wp:term":[{"taxonomy":"brand","embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/etheme_brands?post=5028"},{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product_brand?post=5028"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product_cat?post=5028"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptoscience.com\/es\/wp-json\/wp\/v2\/product_tag?post=5028"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}