{"id":5032,"date":"2026-07-31T07:17:37","date_gmt":"2026-07-31T07:17:37","guid":{"rendered":"https:\/\/peptoscience.com\/?post_type=product&p=5032"},"modified":"2026-07-31T07:17:43","modified_gmt":"2026-07-31T07:17:43","slug":"oxycontin-80mg","status":"publish","type":"product","link":"https:\/\/peptoscience.com\/de\/product\/oxycontin-80mg\/","title":{"rendered":"Oxycontin 80mg"},"content":{"rendered":"

Oxycontin<\/a> 80mg<\/h1>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

OxyContin<\/a> 80mg is a brand-name extended-release formulation of oxycodone hydrochloride<\/strong>, a potent opioid analgesic. The 80mg strength is one of the higher doses, typically prescribed for severe, chronic pain management (e.g., cancer pain or post-surgical recovery) in opioid-tolerant patients. It’s designed for\u00a012-hour dosing<\/strong>\u00a0to provide steady pain relief, not for immediate-release use like breakthrough pain.<\/p>\n

Key Facts and Evidence<\/h4>\n
    \n
  • Pharmacology<\/strong>: Oxycodone is a semi-synthetic opioid agonist binding to mu-opioid receptors in the brain and spinal cord, altering pain perception. The extended-release coating (abuse-deterrent formulation since 2010) uses a polymer matrix to slow dissolution, reducing crushing\/snorting potential. Peak plasma levels occur ~3 hours post-dose; half-life is 4.5 hours (source: FDA prescribing info, Purdue Pharma).<\/li>\n
  • Dosing Guidelines<\/strong>\u00a0(from FDA-approved label):<\/li>\n<\/ul>\n<\/div>\n
    \n\n\n\n\n\n\n
    Patient Type<\/th>\nStarting Dose<\/th>\nTitration<\/th>\nMax Daily<\/th>\n<\/tr>\n<\/thead>\n
    Opioid-naive<\/td>\nNot recommended (use lower strengths like 10-20mg)<\/td>\nIncrease by 25-50% every 1-2 days<\/td>\n80mg (split BID)<\/td>\n<\/tr>\n
    Opioid-tolerant<\/td>\n40-80mg every 12 hours<\/td>\nAdjust based on pain\/response<\/td>\nNo strict max; monitor closely<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
    \n
      \n
    • 80mg specifics<\/strong>: Green-colored, round tablet (OP 80 imprint). Equivalent to ~120mg oral morphine daily when dosed BID. Not for children under 11 or <50kg.<\/li>\n
    • Clinical Efficacy<\/strong>: Studies (e.g., NEJM 2003 trial) show it reduces chronic pain scores by 30-50% in tolerant patients vs. placebo, but tolerance develops quickly (weeks).<\/li>\n<\/ul>\n

      Risks and Side Effects<\/h4>\n

      High-strength doses like 80mg carry\u00a0significant risks<\/strong>, substantiated by CDC data and FDA black-box warnings:<\/p>\n

        \n
      • Overdose<\/strong>: Respiratory depression is primary cause of death. Lethal dose ~200mg in naive users (equianalgesic calculators like CDC’s). Naloxone reverses it.<\/li>\n
      • Common Side Effects<\/strong>\u00a0(>10% incidence): Constipation (40-60%), nausea (23%), drowsiness (23%), itching (15%).<\/li>\n
      • Serious Risks<\/strong>:<\/li>\n<\/ul>\n<\/div>\n
        \n\n\n\n\n\n\n\n\n
        Risk<\/th>\nIncidence\/Evidence<\/th>\nMitigation<\/th>\n<\/tr>\n<\/thead>\n
        Addiction\/Dependence<\/td>\n8-12% in chronic users (JAMA 2014 meta-analysis)<\/td>\nScreen with Opioid Risk Tool; taper slowly<\/td>\n<\/tr>\n
        Respiratory Failure<\/td>\n1-2% hospitalized (per 10,000 scripts, FDA)<\/td>\nMonitor SpO2; avoid alcohol\/Benzos<\/td>\n<\/tr>\n
        Hyperalgesia<\/td>\nParadoxical pain increase (animal\/human studies, Pain 2017)<\/td>\nRotate opioids if suspected<\/td>\n<\/tr>\n
        Neonatal Abstinence (pregnancy)<\/td>\nCategory C; avoid if possible<\/td>\nUse lowest effective dose<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
        \n
          \n
        • Abuse Potential<\/strong>: Pre-2010 versions were crushed for rapid high (e.g., “oxy 80s” street value $40-80\/pill, DEA reports). Reformulated version gels when crushed, but IV abuse still occurs.<\/li>\n<\/ul>\n

          Regulatory and Withdrawal Notes<\/h4>\n
            \n
          • Controlled Substance<\/strong>: Schedule II (high abuse potential, DEA). Requires prescription; no refills without MD approval.<\/li>\n
          • Withdrawal<\/strong>: Abrupt stop causes flu-like symptoms (anxiety, sweats, diarrhea) peaking 72 hours. Taper 10-25% weekly (ASAM guidelines).<\/li>\n
          • Interactions<\/strong>: Potentiated by CYP3A4 inhibitors (e.g., ketoconazole); avoid with MAOIs.<\/li>\n<\/ul>\n

            Recent Context<\/h4>\n

            Post-2010 reformulation reduced abuse rates by 75% (JAMA 2017), but contributed to the opioid crisis (e.g., Purdue’s\u00a0$8B settlement, 2020). Alternatives: fentanyl patches, buprenorphine for maintenance.<\/p>\n

            Disclaimer<\/strong>: This is factual info from FDA, CDC, and peer-reviewed sources (e.g., PubMed). Not medical advice\u2014consult a doctor for personal\u00a0 Misuse can be fatal. If seeking treatment, resources like SAMHSA helpline (1-800-662-HELP) available.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

            <\/div>\n","protected":false},"excerpt":{"rendered":"

            Oxycontin 80mg OxyContin 80mg is a brand-name extended-release formulation of oxycodone hydrochloride, a potent opioid analgesic. The 80mg strength is one of the higher doses,…<\/p>","protected":false},"featured_media":5052,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"etheme_brands":[],"product_brand":[],"product_cat":[62],"product_tag":[206],"class_list":["post-5032","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-oxycontin-80mg","first","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"\nOxycontin 80mg - Peptide Store<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/peptoscience.com\/de\/product\/oxycontin-80mg\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oxycontin 80mg\" \/>\n<meta property=\"og:description\" content=\"Oxycontin 80mg OxyContin 80mg is a brand-name extended-release formulation of oxycodone hydrochloride, a potent opioid analgesic. The 80mg strength is one of the higher doses,...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/peptoscience.com\/de\/product\/oxycontin-80mg\/\" \/>\n<meta property=\"og:site_name\" content=\"Peptide Store\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-31T07:17:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/photo_5186316286194027561_y.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1164\" \/>\n\t<meta property=\"og:image:height\" content=\"1078\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/oxycontin-80mg\\\/\",\"url\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/oxycontin-80mg\\\/\",\"name\":\"Oxycontin 80mg - Peptide Store\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/peptoscience.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/oxycontin-80mg\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/oxycontin-80mg\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/peptoscience.com\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/photo_5186316286194027561_y.jpg\",\"datePublished\":\"2026-07-31T07:17:37+00:00\",\"dateModified\":\"2026-07-31T07:17:43+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/oxycontin-80mg\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/peptoscience.com\\\/product\\\/oxycontin-80mg\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/oxycontin-80mg\\\/#primaryimage\",\"url\":\"https:\\\/\\\/peptoscience.com\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/photo_5186316286194027561_y.jpg\",\"contentUrl\":\"https:\\\/\\\/peptoscience.com\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/photo_5186316286194027561_y.jpg\",\"width\":1164,\"height\":1078},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/peptoscience.com\\\/product\\\/oxycontin-80mg\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/peptoscience.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\\\/\\\/peptoscience.com\\\/it\\\/shop\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Oxycontin 80mg\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/peptoscience.com\\\/#website\",\"url\":\"https:\\\/\\\/peptoscience.com\\\/\",\"name\":\"Peptide Store\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/peptoscience.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/peptoscience.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/peptoscience.com\\\/#organization\",\"name\":\"Peptide Store\",\"url\":\"https:\\\/\\\/peptoscience.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/peptoscience.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/peptoscience.com\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/lacesite_icon.png\",\"contentUrl\":\"https:\\\/\\\/peptoscience.com\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/lacesite_icon.png\",\"width\":513,\"height\":512,\"caption\":\"Peptide Store\"},\"image\":{\"@id\":\"https:\\\/\\\/peptoscience.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Oxycontin 80mg - Peptide Store","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/peptoscience.com\/de\/product\/oxycontin-80mg\/","og_locale":"de_DE","og_type":"article","og_title":"Oxycontin 80mg","og_description":"Oxycontin 80mg OxyContin 80mg is a brand-name extended-release formulation of oxycodone hydrochloride, a potent opioid analgesic. The 80mg strength is one of the higher doses,...","og_url":"https:\/\/peptoscience.com\/de\/product\/oxycontin-80mg\/","og_site_name":"Peptide Store","article_modified_time":"2026-07-31T07:17:43+00:00","og_image":[{"width":1164,"height":1078,"url":"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/photo_5186316286194027561_y.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"2\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/peptoscience.com\/product\/oxycontin-80mg\/","url":"https:\/\/peptoscience.com\/product\/oxycontin-80mg\/","name":"Oxycontin 80mg - Peptide Store","isPartOf":{"@id":"https:\/\/peptoscience.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/peptoscience.com\/product\/oxycontin-80mg\/#primaryimage"},"image":{"@id":"https:\/\/peptoscience.com\/product\/oxycontin-80mg\/#primaryimage"},"thumbnailUrl":"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/photo_5186316286194027561_y.jpg","datePublished":"2026-07-31T07:17:37+00:00","dateModified":"2026-07-31T07:17:43+00:00","breadcrumb":{"@id":"https:\/\/peptoscience.com\/product\/oxycontin-80mg\/#breadcrumb"},"inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/peptoscience.com\/product\/oxycontin-80mg\/"]}]},{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/peptoscience.com\/product\/oxycontin-80mg\/#primaryimage","url":"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/photo_5186316286194027561_y.jpg","contentUrl":"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/photo_5186316286194027561_y.jpg","width":1164,"height":1078},{"@type":"BreadcrumbList","@id":"https:\/\/peptoscience.com\/product\/oxycontin-80mg\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/peptoscience.com\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/peptoscience.com\/it\/shop\/"},{"@type":"ListItem","position":3,"name":"Oxycontin 80mg"}]},{"@type":"WebSite","@id":"https:\/\/peptoscience.com\/#website","url":"https:\/\/peptoscience.com\/","name":"Peptide Store","description":"","publisher":{"@id":"https:\/\/peptoscience.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/peptoscience.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/peptoscience.com\/#organization","name":"Peptide Store","url":"https:\/\/peptoscience.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/peptoscience.com\/#\/schema\/logo\/image\/","url":"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/lacesite_icon.png","contentUrl":"https:\/\/peptoscience.com\/wp-content\/uploads\/2026\/07\/lacesite_icon.png","width":513,"height":512,"caption":"Peptide Store"},"image":{"@id":"https:\/\/peptoscience.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product\/5032","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/comments?post=5032"}],"version-history":[{"count":1,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product\/5032\/revisions"}],"predecessor-version":[{"id":5053,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product\/5032\/revisions\/5053"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/media\/5052"}],"wp:attachment":[{"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/media?parent=5032"}],"wp:term":[{"taxonomy":"brand","embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/etheme_brands?post=5032"},{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product_brand?post=5032"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product_cat?post=5032"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product_tag?post=5032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}