{"id":4942,"date":"2026-07-31T07:17:25","date_gmt":"2026-07-31T07:17:25","guid":{"rendered":"https:\/\/peptoscience.com\/?post_type=product&#038;p=4942"},"modified":"2026-07-31T07:17:36","modified_gmt":"2026-07-31T07:17:36","slug":"codeine-phosphate-2","status":"publish","type":"product","link":"https:\/\/peptoscience.com\/de\/product\/codeine-phosphate-2\/","title":{"rendered":"Codeine Phosphate"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Codeine Phosphate<\/a><\/h1>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharmacy.de\/\">Codeine phosphate<\/a> is the phosphate salt form of codeine, a naturally occurring opioid alkaloid derived from the opium poppy (<em>Papaver somniferum<\/em>). It&#8217;s a prodrug metabolized in the liver (primarily by CYP2D6 enzyme) into morphine, which provides its main analgesic effects. Chemically, it&#8217;s C\u2081\u2088H\u2082\u2081NO\u2083\u00b7H\u2083PO\u2084, with a molecular weight of 406.37 g\/mol.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Medical Uses<\/strong><\/p>\n<ul>\n<li><strong>Pain relief<\/strong>: Mild to moderate pain (e.g., post-surgical, dental). Often combined with acetaminophen (e.g., Tylenol #3) or ibuprofen.<\/li>\n<li><strong>Cough suppression<\/strong>: Antitussive in syrups (e.g., for dry coughs).<\/li>\n<li><strong>Antidiarrheal<\/strong>: In low doses (e.g., as part of Lomotil with diphenoxylate).<br \/>\nDoses typically range from 15\u201360 mg every 4\u20136 hours for adults (max 360 mg\/day), but ultra-rapid CYP2D6 metabolizers may experience toxicity at standard doses.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Pharmacology<\/strong><\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Property<\/th>\n<th>Details<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Class<\/td>\n<td>Opioid agonist (\u03bc-receptor partial agonist)<\/td>\n<\/tr>\n<tr>\n<td>Onset<\/td>\n<td>30\u201360 min (oral); peak 1\u20132 hours<\/td>\n<\/tr>\n<tr>\n<td>Duration<\/td>\n<td>4\u20136 hours<\/td>\n<\/tr>\n<tr>\n<td>Half-life<\/td>\n<td>2.5\u20134 hours (codeine); 2\u20134 hours (morphine metabolite)<\/td>\n<\/tr>\n<tr>\n<td>Bioavailability<\/td>\n<td>~50% oral (first-pass metabolism)<\/td>\n<\/tr>\n<tr>\n<td>Excretion<\/td>\n<td>Urine (10% unchanged; rest as metabolites)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><strong>Side Effects &amp; Risks<\/strong><\/p>\n<ul>\n<li><strong>Common<\/strong>: Drowsiness, constipation, nausea, dizziness, itching.<\/li>\n<li><strong>Serious<\/strong>: Respiratory depression (dose-dependent; risk highest &gt;200 mg\/day), addiction\/dependence, overdose (pinpoint pupils, coma).<\/li>\n<li><strong>Contraindications<\/strong>: Respiratory depression, acute asthma, paralytic ileus, children &lt;12 (FDA black box for cough\/cold due to apnea risk), breastfeeding (morphine in milk).<\/li>\n<li><strong>Interactions<\/strong>: CYP2D6 inhibitors (e.g., fluoxetine) reduce efficacy; sedatives\/alcohol amplify depression.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Legal Status<\/strong><br \/>\nSchedule II controlled substance in the US (high abuse potential); prescription-only worldwide. Overdose treated with naloxone.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Evidence Base<\/strong><\/p>\n<ul>\n<li>WHO Essential Medicines List (analgesic).<\/li>\n<li>Studies (e.g., Cochrane reviews) show modest efficacy for pain\/cough vs. placebo, inferior to stronger opioids like morphine.<\/li>\n<li>Genetic testing recommended for poor\/ultra-rapid metabolizers (e.g., ~10% Caucasians poor; 1\u20132% ultra-rapid).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Fun Fact<\/strong>: Codeine was first isolated in 1832 by Pierre Jean Robiquet. Recreational use often involves extraction from OTC combo pills (e.g., &#8220;lean&#8221; with promethazine), but purity varies wildly.<\/p>\n<h3>Warnings:<\/h3>\n<ul>\n<li><strong>Illegal Sources<\/strong>: Dark web, street dealers, or unregulated foreign sites (e.g., from India\/Mexico) risk counterfeits, fentanyl contamination, arrest, or death. US penalties: Up to 20 years prison\/fines for trafficking.<\/li>\n<li><strong>Global Trends<\/strong>: Interpol\/FDA seize millions in illicit shipments yearly; purity often &lt;50%.<\/li>\n<li><strong>Safer Alternatives<\/strong>: For pain\u2014ibuprofen\/acetaminophen; cough\u2014dextromethorphan (OTC).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Not medical\/legal advice\u2014check local laws (e.g., DEA.gov, EMA.europa.eu).<\/strong>\u00a0If you need it for health reasons, talk to a doctor.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Codeine Phosphate Codeine phosphate is the phosphate salt form of codeine, a naturally occurring opioid alkaloid derived from the opium poppy (Papaver somniferum). It&#8217;s a&#8230;<\/p>","protected":false},"featured_media":4973,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"etheme_brands":[],"product_brand":[],"product_cat":[15],"product_tag":[188],"class_list":["post-4942","product","type-product","status-publish","has-post-thumbnail","product_cat-uncategorized","product_tag-codeine-phosphate","first","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Codeine Phosphate - Peptide Store<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/peptoscience.com\/de\/product\/codeine-phosphate-2\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Codeine Phosphate\" \/>\n<meta property=\"og:description\" content=\"Codeine Phosphate Codeine phosphate is the phosphate salt form of codeine, a naturally occurring opioid alkaloid derived from the opium poppy (Papaver somniferum). 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