{"id":4921,"date":"2026-07-31T07:17:25","date_gmt":"2026-07-31T07:17:25","guid":{"rendered":"https:\/\/peptoscience.com\/?post_type=product&p=4921"},"modified":"2026-07-31T07:17:26","modified_gmt":"2026-07-31T07:17:26","slug":"contrave-tablets","status":"publish","type":"product","link":"https:\/\/peptoscience.com\/de\/product\/contrave-tablets\/","title":{"rendered":"Contrave Tablets"},"content":{"rendered":"

Contrave Tablets<\/a><\/h1>\n
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Contrave tablets<\/a> (naltrexone HCl and bupropion HCl extended-release tablets) is a prescription medication approved by the FDA in 2014 for chronic weight management<\/strong>\u00a0in adults with obesity (BMI \u226530 kg\/m\u00b2) or overweight (BMI \u226527 kg\/m\u00b2) who have at least one weight-related comorbidity, such as type 2 diabetes, hypertension, or dyslipidemia. It is used\u00a0as an adjunct to a reduced-calorie diet and increased physical activity<\/strong>. It is\u00a0not intended for cosmetic weight loss<\/strong>\u00a0or short-term use.<\/p>\n

How It Works<\/h4>\n

Contrave combines two active ingredients:<\/p>\n

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  • Naltrexone HCl<\/strong>\u00a0(8 mg per tablet): An opioid receptor antagonist that may reduce appetite and food cravings by modulating reward pathways in the brain (e.g., blocking the hedonic effects of food).<\/li>\n
  • Bupropion HCl<\/strong>\u00a0(90 mg per tablet): A norepinephrine-dopamine reuptake inhibitor (NDRI) antidepressant that helps suppress appetite and may increase energy expenditure.<\/li>\n<\/ul>\n

    The extended-release formulation provides 24-hour coverage. Typical dosing starts at 1 tablet (8\/90 mg) once daily for Week 1, escalating to a maximum of\u00a02 tablets twice daily<\/strong>\u00a0(total 32\/360 mg\/day) by Week 4, if tolerated.<\/p>\n

    Evidence<\/strong>: Clinical trials (e.g., COR-I and COR-II studies) showed ~5% average weight loss over 56 weeks vs. placebo (4-5% responders achieving \u22655% loss). A 2020 meta-analysis in\u00a0Obesity Reviews<\/em>\u00a0confirmed modest efficacy (3-5 kg more than placebo) but emphasized lifestyle integration.<\/p>\n

    Dosage Forms<\/h4>\n
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    • Strength<\/strong>: 8 mg naltrexone \/ 90 mg bupropion per oblong, film-coated tablet (yellow; imprinted “8\/90”).<\/li>\n
    • Packaging<\/strong>: Bottles of 60 or 120 tablets (28-day or 56-day supply at max dose).<\/li>\n
    • Administration<\/strong>: Swallow whole with water; take with meals to reduce nausea. Avoid crushing\/chewing.<\/li>\n<\/ul>\n

      Common Side Effects<\/h4>\n<\/div>\n
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      Category<\/th>\nFrequent (>5%)<\/th>\nSerious (Rare)<\/th>\n<\/tr>\n<\/thead>\n
      GI<\/td>\nNausea (32-36%), constipation (19%), vomiting (10-11%), diarrhea (7-9%)<\/td>\n\n
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      • <\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
      Neuropsych<\/td>\nHeadache (18%), dizziness (9-10%), insomnia (9%), dry mouth (8%)<\/td>\nSeizures (0.1%; risk \u2191 with dose\/history), suicidal thoughts (black box warning)<\/td>\n<\/tr>\n
      CV<\/td>\nIncreased heart rate (\u21915-9 bpm), hypertension<\/td>\nIncreased BP\/HR<\/td>\n<\/tr>\n
      Other<\/td>\nHyperhidrosis (sweating, 6-7%)<\/td>\nGlaucoma (angle-closure), allergic reactions, hepatotoxicity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
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      Discontinuation<\/strong>: Taper if stopping bupropion to avoid withdrawal; naltrexone has no taper needed.<\/p>\n

      Contraindications & Warnings<\/h4>\n
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      • Absolute<\/strong>: Uncontrolled hypertension, seizures\/epilepsy, bulimia\/anorexia history, chronic opioid use (precipitates withdrawal), MAOI use (within 14 days), pregnancy (Category X).<\/li>\n
      • Precautions<\/strong>: Monitor BP\/HR; avoid alcohol (seizure risk); not for smokers quitting (use Zyban instead). Hepatic\/renal impairment requires dose adjustment.<\/li>\n
      • Drug Interactions<\/strong>: Strong CYP2B6 inhibitors (e.g., ticlopidine) \u2191 bupropion levels; opioids\/dextromethorphan blocked by naltrexone.<\/li>\n<\/ul>\n

        Availability & Cost<\/h4>\n
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        • Brand-only<\/strong>\u00a0(no generic as of 2024).<\/li>\n
        • US retail: ~1,300\/month without insurance; copay cards from manufacturer (Currax) can reduce to\u00a099.<\/li>\n
        • Covered by many insurers for eligible patients.<\/li>\n<\/ul>\n

          Important<\/strong>: This is general information based on FDA labeling, prescribing info (currax.com), and studies (e.g., NEJM 2010; JAMA 2015).\u00a0Consult a healthcare provider<\/strong>\u00a0for personalized advice, as Contrave requires a Risk Evaluation and Mitigation Strategy (REMS) program enrollment due to seizure risk. Do not self-medicate. If experiencing side effects, seek medical help immediately.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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          Contrave Tablets Contrave tablets (naltrexone HCl and bupropion HCl extended-release tablets) is a prescription medication approved by the FDA in 2014 for chronic weight management\u00a0in…<\/p>","protected":false},"featured_media":4952,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"etheme_brands":[],"product_brand":[],"product_cat":[56],"product_tag":[189],"class_list":["post-4921","product","type-product","status-publish","has-post-thumbnail","product_cat-weight-loss","product_tag-contrave-tablets","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product\/4921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/comments?post=4921"}],"version-history":[{"count":1,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product\/4921\/revisions"}],"predecessor-version":[{"id":4953,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product\/4921\/revisions\/4953"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/media\/4952"}],"wp:attachment":[{"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/media?parent=4921"}],"wp:term":[{"taxonomy":"brand","embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/etheme_brands?post=4921"},{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product_brand?post=4921"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product_cat?post=4921"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptoscience.com\/de\/wp-json\/wp\/v2\/product_tag?post=4921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}